B.S. University of Connecticut, Animal Science, 1985
M.S. University of Florida, Reproductive Biology, 1988
Ph.D. Univeristy of Florida, Reproductive Biology, 1992
Area(s) of Expertise:
Neuroendocrinology, Neurodegenerative Disorders, Diabetes, Ketogenic Diet, Calorie Restriction
Current research focuses on the effects of the ketogenic diet on brain energy metabolism, seizure susceptibility and behavior.
- Ketogenic diet and brain energy metabolism
- Caloric restriction
- Neurodegenerative disorders
- Neuroendocrine control of reproduction
- Brain aging
Harney, JP., M.A. Monsey, J. Talluri & J. Meade, 2009. Effects of ketogenic diets on blood glucose, ketones, plasma lipids and cholesterol in streptozotocin-induced diabetic rats. J. Nutrition (In preparation).
A.A. Walf, M.E. Rhodes, J.R. Meade, J.P. Harney & C.A. Frye, 2007. Estradiol-induced conditioned place preference may require acions at estrogen receptors in the nucleus accumbens. Neuropsychopharmacology 32:522-30
Frye, C.A.,K. Sumida, B.C. Dudek, J.P. Harney, J.P. Lydon, B.W. O'Malley, D.W. Pfaff & M.E. Rhodes, 2006. Progesterone's effects to reduce anxiety behavior of aged mice do not require actions viab intracellular progrestin receptors . Psychopharmacology 186:312-22.
Frye, C.A., M.E. Rhodes, J. Talluri & J.P. Harney, 2005. Ketogenic diet decreases circulating concentrations of neuroactive steroids in female rats. Epilepsy Behav 7:231-9.
Frye, C.A., A.A. Walf, M.E. Rhodes & J.P. Harney. 2004. Progesterone enhances motor, anxiolytic, anlgesic, and antidepressive behavior of wild type mice, but not those deficient in 5 alpha reductase. Brain Research 1004(1-2):116-124.
Rhodes, M.E., J.P. Harney & C.A. Frye. 2004. Gonadal, adrenal, and neuroactive steroids' role in ictal activity. Brain Research 1000(1-2):8-18.
Frye, C.A., M.E. Rhodes, A. Walf & J.P. Harney. 2002. Progesterone reduces pentylenetetrazol-induced ictal activity of wild type mice but not those deficient in Type I 5 alpha reductase. Epilepsia 43(s5):14-17.
Frye, C.A., M.E. Rhodes, A. Walf & J.P. Harney. 2002. Testosterone enhances aggression of wild type mice but not those deficient in Type I 5 alpha reductase. Brain Research 948(1-2):165-170.
Harney, J.P., J. Madara, J. Madara & H. I'Anson. 2002. Effects of acute inhibition of fatty acid oxidation on latency to seizure and concentrations of beta-hydroxybutyrate in plasma of rats maintained on calorie restriction and/or the ketogenic diet. Epilepsy Research 49:239-246.
Frye, C.A., M.E. Rhodes, A. Walf & J.P. Harney. 2001. Testosterone reduces pentylenetetrazol-induced ictal activity of wild type mice but not those deficient in Type I 5 alpha reductase. Brain Research 918:182-186.
Hinkle, D.A., J.P. Harney, A. Cai, D.C. Hilt, P.J. Yarowsky & P.M. Wise. 1997. Basic fibrolast growth factor-2 and interleukin-1beta expression in cultured astrocytes. Neuroscience 82:33-41.
Wise, P.M., M.L. Kashon, K.M. Krajnak, K.L. Rosewell, A. Cai, K. Scarbrough, J.P. Harney, T. McShane, J.M. Lloyd & N.G. Weiland. 1997. Aging of the female reproductive system: a window into brain aging. Recent Progess Hormone Research 52:279-305.
Harney, J.P., K. Scarbrough, K.L. Rosewell & P.M. Wise. 1996. In vivo antisense antagonism of vasoactive intestinal polypeptide in the suprachiasmatic nuclei causes aging-like changes in the estradiol-induced luteinizing hormone and prolactin surges. Endocrinology 137:3696-3701.